Determination of urinary estriol excretion as a measure of placental function and intrauterine fetal well-being has been evaluated in obstetrics and has proved to be of diagnostic value.
To the author´s knowledge, there has not been a report of urinary estriol excretion in pregnancy in Korea. This study is designed to - measure urinary estriol excretion in normal pregnancy and some complicated. pregnancies as well. Comparison with the results of various author´sis also
done. It is also designed to evaluate clinical applicability and practicability.
Material and Method
Subjects were 241 pregnant women who were registered in prenatal clinic of the department.-of obstetrics_of Yoasei University College of Medicine. 308 determinations were carried out from the, 20th week to 45th week of gestation..
Determination of urinary.estriol excretion was carried out by the modified Brown´s: method (19 57) with- a 24´ hour´s urine specimen.,,
A total of 80 complicated .pregnancies were tested as follows;
1. 28 cases of toxemia of pregnancy (severe form of preeclampsia and eclampsia) and hypertension.
2. 6 cases of pyelonephritis.
3. 6 cases of hydatidiform mole.
4. 14 cases of known intrauterine: fetal death and 7 cases of intrauterine fetal death -that- occu Tred during´-treatmentof complications after admission.
5. 18 case of overdue.
6. 5o anencephalus.
In twelve of 161 normal pregnancies, urinary estriol value has been, followed biweekly from 20th week´s gestation to term.
Conclusion
The results of urinary estriol excretion determination that-; are_ carried out: are summarized as
follows;
1:= In normal pregiaancies there was a gradual increase in urinary estriol excretion and mean
value of urinary estriol was 4: 3mg/24hrs at 20th, week, gestation and .28.9mg/24hrs at term 2.Then pregnancy vas complicated with hypertension,=toxemia or pyelonephritis,´-_the_ urinary on bevel was lower than. not mal pregnancy.
R . =n{ :r -´ ~. y 3. If the value of urinary estriol excretion at term is less than 4. Omg/24hours, intrauterine fetal -death can be diagnosed and if more than 12mg/hour, fetal well-being can be diagnosed. 4. Urinary estriol excretion was markedly decreased in the hydatidiform mole and anencephalus. 5. Urnary estriol excretion was decreased in overdue pregnancy and the normal loweir limit of the urinary estriol excretion was 12. Omg/24 hours.
6. Urinary estriol excretion of l2mg/24 hours or more at term suggested mature fetus.
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